Transforming agro-food to advance food security while promoting sustainable industrialisation in developing countries is an urgent priority. Intermediary cities, as vital connectors between urban and rural areas, are piloting innovative solutions to drive this transformation through food-tech. This policy brief examines how innovation ecosystems in intermediary cities can contribute to achieving net-zero emissions and zero hunger and presents key recommendations for development policy. It has been prepared within the framework of the G20 Platform on SDG Localisation and Intermediary Cities (PLIC) under the South African G20 Presidency.